The shooting happened early on Monday morning in the east of the city, the Orlando Sentinel newspaper reported.
This tragedy comes a week before the first anniversary of the Pulse nightclub shooting in the city – the deadliest mass shooting in US history – in which 49 people died.
Police said the scene of the shooting had been “stabilised”, indicating the shooting was not ongoing. Reports in Florida said the deaths occurred at a business.
In last June’s attack, gunman Omar Mateen killed 49 people and injured dozens more at a gay nightclub before being shot dead by police.